I’ve been making this Chicken Alfredo Lasagna for years when I want something creamy, comforting, and a little fancier than plain pasta night. It layers tender shredded chicken with a rich homemade Alfredo, ricotta, mozzarella and Parmesan between lasagna noodles for a crowd-pleasing bake that’s perfect for weeknights, potlucks, or a relaxed Sunday supper.

Why you’ll love this dish

This lasagna takes the familiar comfort of chicken Alfredo and turns it into a handheld, fork-ready casserole everyone fights over. It’s creamy without being heavy, easy to assemble with leftover or rotisserie chicken, and adapts well to picky eaters (leave out the spinach, add extra cheese). Make it when you want an elevated weeknight dinner or a simple Sunday meal that feeds a family with minimal fuss.

“Rich, velvety sauce and tender chicken—our whole family asked for seconds. Perfect weeknight comfort food.”

I often pair this lasagna with lighter sides so the richness doesn’t feel overwhelming. If you like other crowd-pleasing casseroles, check out this take on Buffalo Chicken Lasagna for a spicy spin.

The cooking process explained

Before you dive in, here’s the short version so you know what to expect:

Cook noodles and prep fillings (shred the chicken, make or heat Alfredo).
Build layered rounds: sauce, noodles, chicken + ricotta (+ spinach if using), mozzarella, then more sauce.
Cover and bake 25 minutes, uncover and brown 10–15 minutes more.
Rest briefly, slice, and serve.

This recipe is straightforward and forgiving—ideal if you want something impressive with minimal technique. If you prefer stuffed pastas, you might also like these chicken broccoli Alfredo stuffed shells as an alternative.

What you’ll need

Lasagna noodles (regular or oven-ready; for oven-ready, skip boiling)
Cooked chicken, shredded (rotisserie chicken works great)
Homemade Alfredo sauce (see notes) or store-bought
Parmesan cheese, freshly grated
Mozzarella cheese, shredded
Ricotta cheese
Fresh spinach (optional — baby spinach is easiest)
Salt and black pepper
Olive oil (for greasing if needed)

Notes and substitutions:

Use store-bought Alfredo for speed, but a simple homemade version (butter, heavy cream, garlic, and freshly grated Parmesan) tastes brighter.
Swap ricotta for cottage cheese blended smooth if you prefer a lighter texture.
For a lower-fat option, use part-skim mozzarella and reduce the cream in the sauce, or try this creamy chicken Alfredo pasta for a lighter Alfredo approach.

Directions to follow

Preheat your oven to 375°F (190°C). Lightly oil a 9×13-inch baking dish.
Cook lasagna noodles according to the package directions if using regular noodles. Drain and lay them flat to prevent sticking.
If your Alfredo is not ready, warm or make it now. Aim for a smooth, pourable consistency—not too thick, not too thin.
Spread a thin layer of Alfredo on the bottom of the baking dish to stop noodles from sticking.
Build the first layer: noodles, a generous handful of shredded chicken, dollops of ricotta, a layer of spinach (if using), and a sprinkle of mozzarella. Spoon a thin layer of Alfredo over the top.
Repeat layers (noodles → chicken → ricotta → spinach → mozzarella → Alfredo) until you reach the top of the dish. Finish with a final layer of noodles, the remaining Alfredo, and a generous dusting of Parmesan.
Cover the dish tightly with foil and bake for 25 minutes.
Remove the foil and bake uncovered for another 15 minutes, or until the cheese is bubbly and loosens a light golden crust.
Let the lasagna rest for 5–10 minutes before slicing so the layers set and it serves cleanly.

Best ways to enjoy it

Serve slices with a crisp green salad dressed in lemon vinaigrette to cut through the richness. Garlic bread or toasted baguette is a classic companion. For a complete plate:

Light Caesar or arugula salad with shaved Parmesan
Steamed green beans or roasted asparagus for crunch
A glass of Chardonnay or a light-bodied red like Pinot Noir complements the creamy sauce

For plating, spoon a bit of extra warmed Alfredo on the plate before placing a slice of lasagna on top for a restaurant-style presentation. If you want shareable sides, try pairing with these garlic Parmesan lasagna roll-ups for an indulgent spread.

Storage and reheating tips

Refrigerator: Cool the lasagna to room temperature (no more than 2 hours at room temp). Store in an airtight container or cover the baking dish with foil/plastic wrap for up to 3–4 days.
Freezer: Portion individual slices, wrap tightly in plastic wrap and foil, and freeze for up to 2–3 months. Label with date.
Reheat from refrigerated: Cover with foil and bake at 350°F (175°C) until warmed through, about 15–25 minutes depending on portion size. Alternatively, microwave single slices until hot, stirring the center if needed.
Reheat from frozen: Thaw overnight in fridge, then bake covered at 350°F until heated through. If baking frozen, heat at 350°F for about 45–60 minutes covered, removing foil for last 10–15 minutes.
Food safety: Always reheat until the internal temperature reaches 165°F (74°C) and discard leftovers after 4 days.

Helpful cooking tips

Use freshly grated Parmesan for a cleaner melt and better flavor than pre-grated jars.
If using oven-ready noodles, slide them in dry but ensure sauce layers are generous so they hydrate while baking.
Shred chicken finely so it layers evenly and every bite has protein.
Don’t over-sauced the bottom layer—just a thin layer of sauce prevents sticking without making the lasagna watery.
Let it rest after baking; this makes cleaner slices and stops the sauce from spilling when you cut it.

Creative twists

Add mushrooms and caramelized onions for an earthy variation.
Swap chicken for shredded turkey to use holiday leftovers.
Use a mix of fontina and mozzarella for a silkier melt.
Make it spicy by stirring in red pepper flakes to the Alfredo or layering in a thin spread of pesto or sun-dried tomato paste for brightness.
For a lighter version, substitute Greek yogurt mixed with a little milk for some of the ricotta (use caution with heat—stir in at the end).

Your questions answered

Q: Can I use rotisserie chicken?
A: Absolutely. Rotisserie chicken is a perfect shortcut—shred it and layer as directed. Ensure the chicken is hot or at least room temperature when assembling for a more even bake.

Q: Can I make this ahead of time?
A: Yes. Assemble the lasagna, cover tightly, and refrigerate up to 24 hours before baking. If baking straight from the fridge, add 5–10 minutes to the covered baking time.

Q: Is it safe to freeze?
A: Yes. Wrap portions tightly and freeze up to 2–3 months. Thaw overnight in the fridge before reheating for best texture.

Q: Can I make this gluten-free?
A: Use gluten-free lasagna noodles (or thin slices of roasted eggplant or zucchini) and verify your Alfredo ingredients are gluten-free.

Conclusion

Chicken Alfredo Lasagna is a reliably comforting dish that’s easy to scale for family dinners or entertaining. For more ideas on similar recipes and variations, see this detailed Easy Chicken Alfredo Lasagna guide and this classic Lasagna Alfredo Recipe for further inspiration.